Note: Only a member of this blog may post a comment. The authors expanded on their findings further: However, the impression we get from our experience in epidemiological studies monitoring[12] is that this drug should be prescribed more cautiously. 'A new Italian study published in the journal Reproductive Biology and Endocrinology titled, "Levothyroxine and lung cancer in females: the importance of oxidative stress," has raised a concerning possibility: levothyroxine (T4), one of the world's most commonly prescribed forms of hormone replacement, may be raising the risk of lung cancer in millions of men and women being treated for low thyroid function (hypothyroidism). That's all. J Exp Biol 2010, 213:28992911. The aim of the study was to assess the occurrence and nature of immune-related endocrine adverse events (irAEs) among patients with non-small-cell lung cancer (NSCLC) treated with nivolumab. [14] In other words, you can 'normalize' the main clinically measurable parameter associated with 'low thyroid function,' i.e. Different strokes for different folks for sure! Overtreatment, of course, is the hallmark danger of overdiagnosis. Metab.87 (2): 48999. Endocrinol. Whereas a patient who had suboptimal thyroid function, but did not have noticeable symptoms, is suddenly given pharmacological doses of synthetic T4 and suddenly experiences the wide range of acute, adverse health effects associated with a now hyperactive and/or increasingly disrupted thyroid, as a result. [10] Hofer T, Desbaillets I, Hpfl G, Wenger RH, Gassmann M: Characterization of HIFD-1 alpha overexpressing Hela cells and implication for gene therapy. Curr Opin Endocrinol Diabetes Obes 2010, 17:432436. I don't think so. Data sources: The Medline and Cochrane Library electronic databases . [3], An old clinical observation on the relationship between lung cancer and thyroid function reported that patients were characterized by a low concentration of T3 and an increased T4/T3 ratio due to a decrease of 5-monodeiodination (DI). They then correlated drug sales with cancers, eliminating the contribution of age and smoking for lung cancer risk. Clin Cancer Res 2011, 30:77. 'A new Italian study published in the journal Reproductive Biology and Endocrinology titled, "Levothyroxine and lung cancer in females: the importance of oxidative stress," has raised a concerning possibility: levothyroxine (T4), one of the world's most commonly prescribed forms of hormone replacement, may be raising the risk of lung cancer in millions of men and women being treated for low . [11] Wan J, Chai H, Yu Z, Ge W, Kang N, Xia W, Che Y: H1F-1 on angiogenic potential in human small cell carcinoma. Cookie Notice Capmatinib (Tabrecta) is the first FDA-approved MET-targeting medication for treating metastatic NSCLC. The relationship between levothyroxine use and cancer risk is largely underdetermined. 2013 May ;98(5):1982-90. I hope that with increased knowledge we will all find the right road. Why not simply call it selenium deficiency? Curr Opin Endocrinol Diabetes Obes 2010, 17:432436. Angiology 2000, 51:S65S68. Join the forum, it's quick and easy . There is also the very real possibility that T4 will not only not properly interact with thyroxine cellular receptors, but will block out what remaining natural levothyroxine the thyroid is still producing (and whose conformational state is far more health-promoting), essentially acting as an endocrine disrupter at the very moment that it is acting as intended as a TSH suppressor. This T4 blocking/endocrine-disrupting property of the synthetic form would also activate a negative feedback loop within the endocrine system, further suppressing remaining thyroid function, and resulting in the atrophy of the compromised thyroid, a iatrogenic self-fulfilling prophecy if you will. Nah, I would give this much credence. In addition, untreated hypothyroidism is associated with a gradual decline in cognitive function and memory. [11] Wan J, Chai H, Yu Z, Ge W, Kang N, Xia W, Che Y: H1F-1 on angiogenic potential in human small cell carcinoma. Most of the time, doctors tell patients treated with LT4 that any side effects will be temporary and almost ineluctable, and are usually dealt with through dose reduction. Sin un requerimiento, el cumplimiento voluntario por parte de tu Proveedor de servicios de Internet, o los registros adicionales de un tercero, la informacin almacenada o recuperada slo para este propsito no se puede utilizar para identificarte. They only reappear when I need to fine tune the medication. You are using an out of date browser. I don't believe there are thousands of people on to high a dose of t4, so why does it feel they are hyper? Acta Endocrinol 1988, 118:460464. According to data from the National Health and Nutrition Examination Survey, years 1988-1994, [13] while 0.3% of the American population exhibits overt symptoms of hypothyroidism, 14 times more (4.3%) have so-called subclinical hypothyroidism only detected via blood work. Or, simply look at what the young-adult,T-score based definition of osteoporosis and osteopeniahas done to convert millions of healthy middle-age and older women into drug-treatable patients, or, what the lipid hypothesis of cardiovascular disease causation has done to create a 30-billion dollar a year market in statin drugs, to fully appreciate the harms of overdiagnosis and overtreatment. The authors expanded on their findings further: "However, the impression we get from our experience in epidemiological studies monitoring[12] is that this drug should be prescribed more cautiously. [6] Venditti P, Di Stefano L, Di Meo S: Oxidative stress in cold induced hyperthyroid state. Or that it was the many years of not being diagnosed with hypothyroidism, courtesy of daft blood test ranges, before finally tipping a TSH over 5 (or even 10) before treatment is commenced, by which time the damage is done. In the United States, autoimmune thyroid disease (Hashimoto thyroiditis) is the most common cause of hypothyroidism, but globally lack of iodine in the diet is the most common cause. video where the doc is talking about the study , i wlll link study and video below. [1] Hercbergs AH, Ashur-Fabian O, Garfield D: Thyroid hormone and cancer: clinical studies of hypothyroidism in oncology. Furthermore, the geometric expansion of hypothyroidism cases in the past decade only thinly conceals an agenda to promote the synthetic form of T4 known as levothyroxine sodium (trade name Synthroid), since with each new disease case the patient is converted into a lifelong customer. Thank you for posting it, I agree we all need as much knowledge as we can get! Methods: The study group included 35 patients (15 women, 20 men, 65.8 7.1 years) with NSCLC in stage IIIB (n = 16, 45.7%) and IV (n = 19,54.3%) who were treated with nivolumab. [15] [16]There is also the more logical option of support the bodys thyroid-hormone producing capabilities using the thyroxine precursor L-tyrosine, a basic amino acid with a relatively high margin of safety. But what can be done for patients who are at low But that's just me. This discussion has been closed to comments. Baked or Fried avocado fries [Vegetarian]. Oops, I just saw that I posted the same article. Correlation is not causation. I will respond more later onBut I will briefly say I was on Synthyroid from 1993 to 2011. An Italian study published in the journalReproductive Biology and Endocrinology,titled Levothyroxine and lung cancer in females: the importance of oxidative stress, has raised a concerning possibility: levothyroxine (T4), one of the worlds most commonly prescribed forms of hormone replacement, may be raising the risk of lung cancer in millions of men and women being treated for low thyroid function (hypothyroidism). Non-ASPS articles which could be relevant. However, they pointed out that the opposite was actually described, and that hypothyroidism reduces the aggressiveness of some cancers because of the presence of thyroid hormone receptors on cancer cells, and spontaneous hypothyroidism may delay onset or reduce aggressiveness of cancers.[1]. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional. (They noted that this age range corresponds to more than 80% of the consumers of the drug and to about 99% of all malignant cancers). Thank you for bringing it to our attention. Whereas a patient who had suboptimal thyroid function, but did not have noticeable symptoms, is suddenly given pharmacological doses of synthetic T4 and suddenly experiences the wide range of acute, adverse health effects associated with a now hyperactive and/or increasingly disrupted thyroid, as a result. Allthewebsites Directory - A niche web directory offering website promotion and other webmaster resources. Post author By ; Post date jaripeo hillsboro oregon 2021; what task do they have at camp westerbork on millions treated for hypothyroidism at risk for lung cancer on millions treated for hypothyroidism at risk for lung cancer Considering that the population in Italy is about 60 million people and the sales of LT4 in the country in 2010 were 17.69 million boxes (+ 6% Vs 2009), hypothyroidism, which is the main reason for the prescription, should be a real national concern (almost 0.7 boxes/women/year). See more of Keri Topouzian, D.O. is the fiec part of the evangelical alliance; townhomes in avalon park; 8 ft windmill parts; why is my cash and sweep vehicle negative; nordstrom rack return policy worn shoes I honestly do not know. Study: Millions Treated for Hypothyroidism At Risk of Lung Cancer. I am convinced that my lung cancer is related to the thyroid/auto immune issues I've had for years. However, they pointed out that the opposite was recently described, and that "hypothyroidism reduces theaggressiveness of some cancers because of the presence of thyroid hormone receptors oncancer cells, and spontaneous hypothyroidism may delay onset or reduce aggressiveness ofcancers."[1]. 500+ pages of Natural Medicine Alternatives and Information. Levothyroxine therapy and serum free thyroxine and free triiodothyronine concentrations. View the data on GreenMedInfos Hypothyroidism Research page. Thyroid disease is a major public health concern worldwide. BUT, this is the first I have heard of the potential risk of lung cancer in those who take Synthyroid. At GreenMedInfo.com, we have indexed plenty of peer-reviewed research on over 30 natural substances, including nutrients and minerals, which may help to resolve low thyroid function, and conversely, over 30 unnatural substances, e.g. Overtreatment, of course, is the hallmark danger of overdiagnosis. The authors did not study whether individuals who took Synthroid actually developed lung cancer later in life. The Goji Berry: The Jolly Super Food That Gives Yo How to Prevent and Treat Insect Bites Without Hars Supreme Court Rules Drug Companies Exempt From Law Spain Study Confirms Hemp Oil Cures Cancer without Wheatgrass Turns Gray Hair Back to Its Natural Color, Medicinal Cannabis Used To Prevent Cancer Growth. I am just as much in the dark as some others on this site. Or, simply look at what the young-adult, T-score based definition of osteoporosis and osteopenia has done to convert millions of healthy middle-age and older women into drug-treatable patients, or, what the lipid hypothesis of cardiovascular disease causation has done to create a 30-billion dollar a year market in statin drugs, to fully appreciate the harms of overdiagnosis and overtreatment. Angiology 2000, 51:S65S68. Biomedicine today is awash in controversy associated with the overdiagnosis and overtreatment of asymptomatic populations. As I am the caregiver for my dad who has Stage IV lung Cancer, I hope more research can be done on this topic soon. "A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases.' It looks at correlations, as if they had any merit on their own. Si as lo deseas puedes revisar el resto de nuestros contenidos para encontrar lo que buscabas o directamente utilizar nuestro buscador. Hashimoto's disease progresses slowly over the years. Due to excessive bot signups along with nefarious actors we are limiting forum registration. I invite those interested to read it and perhaps we can have a discussion on this study. Cancer-related fatigue (CRF) is common in lung cancer survivors and can occur at any point in the care continuum. Compression of the trachea, which may be positional, can occur with nodular goiters and thyroid cancer, and the latter can metastasize to the lungs. Brit Med J 1978, 1:210212. JavaScript is disabled. Not what people like me are saying. Results indicate that treatment with levothyroxine was linked with significantly increased mortality (hazard ratio = 1.19). I think part of sharing information here on Inspire is the discussions about the articles we share. So I will leave it as a simple thank you for passing this along. To investigate the magnitude of the possible association between levothyroxine use and cancer risk, this retrospective c I've been on synthroid for 20+ years, scary. As you know, I appreciate people posting links that help us learn more about lung cancer, too. I have been reading Izabella Wentz. This relatively symptom-free reservoir of hypothyroid cases provides a veritable gold mine of potential office visits, billable services and drug prescriptions. It does not seem to quantify the increased risk, and it keeps saying it is hyperthyroidism that causes the oxidised stress. The article also stresses that too many people are being given the diagnosis of either hypo or hyperthyroidism. It was the therapist that I went to that referred me to a specialist who ran the correct tests. In 2011 I switched docs and was put on Armour as he told me Synthroid and the like are poison and they do not work. Are you sure you want to block this member? El almacenamiento o acceso tcnico que es utilizado exclusivamente con fines estadsticos. Now, I will bring it to the attention of my Endocrinologist. Endocrinology 1985, 117:12011208. Patient characteristics. I have no further scientific evidence. Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer. You must log in or register to reply here. Hypothyroidism results from low levels of thyroid hormone with varied etiology and manifestations. Hypothyroidism reduces respiratory drive and can cause obstructive sleep apnea or pleural effusion, while hyperthyroidism increases respiratory drive and can cause dyspnea on exertion. They also noted that oxidative stress is one of the causes of chronic diseases and cancer. Or, if fluoride, mercury, or any number of xenobiotic chemicals in the environment requiring selenium-dependent glutathione-mediated detoxification is causing the "low thyroid," why call chemical poisoning "hypothyroidism"? For more, visitGreenMedInfo.comand Facebook.com/GreenMedInfo, or sign up forGreenMedInfos free e-Newsletter. A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases.'. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. El almacenamiento o acceso tcnico es necesario para crear perfiles de usuario para enviar publicidad, o para rastrear al usuario en una web o en varias web con fines de marketing similares. PLoSone 2011, 11:e27547. There is also compelling research indicating that desiccated thyroid extract (Armour thyroid) results in superior clinical outcomes versus the synthetic hormone, especially as concerns improved body weight. Researchers are currently studying. Heart problems. 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Sub-laboratory hypothyroidism and the empirical use of Armour thyroid.Altern Med Rev. J Exp Biol 2010, 213:28992911. Based just on this article, I think the study's conclusion that Synthroid may cause an increase in lung cancer risk is premature. The study looked at the prevalence of breast, colorectal, gastric and lung cancer in 18 Italian Regions during 2010 and correlated this data with sales of LT4 in 2009, focusing on women aged 30-84. Given the clear role that selenium deficiency plays in preventing the conversion of T4 to the far more biologically active form of thyroid hormone known as triiodothyronine (T3), which can cause an elevation of thyroxine-stimulating hormone (TSH), why call a mineral deficiency-induced decrease in T4 a monolithic disease entity such as hypothyroidism? If I can help someone, fine. Is This the Real Reason You're Exhausted All the T Why An Alkaline Approach Can Successfully Treat Ca We're Losing the War on Cancer- Here's Why. This is a horrible disease that ravages the body. Also, what is oxidised stress??? Why not simply call it selenium deficiency? Maybe because they "treat" only with T4 and not T3? They found no significant correlation between T4 sales and breast, colorectal and gastriccancers, but did find a significant correlation for lung cancer (p < 0.05) corrected forsmoking and age. Modern Medicine, Part I: How Healing Illness Becam Is your body getting too acidic? [2], The observation that patients with small cell carcinoma of the lung often present symptoms suggestive of hyperthyroidism (i.e. Acta Endocrinol 1988, 118:460464. ", Orsomeone posts something about, say a diet or supplement and them some people think they are something it "Cures lung cancer.". millions treated for hypothyroidism at risk for lung cancer. A study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related diseases.. Tokushima J Exp Med 1991, 38:2535. The great open sky of imagination: for those who u Fermented Foods: Top 8 Reasons to Eat Them. Endocrinology 1985, 117:12011208. In fact, it is the high levels of T4 that make them more susceptible to cancer. PMID 11836274. J Clin Endocrinol Metab. Could be another marmalade how would we know? Objectives: To examine site-specific cancer incidence and mortality and to evaluate the radiation dose-response association after RAI treatment for hyperthyroidism. Oops I have just bought my first jar of marmalade in over ten years! [7] They also elaborate on a mechanism of T4-induced lung tissue toxicity: [I]n rats lung the deiodination of LT4 is the lowest compared to all the other tissues. In discussing their findings, the authors noted that they could not exclude the possibility that the condition of hypothyroidism could favor the development of lung cancer. Log In. Obesity epidemic caused by EMF exposures in the ho War on Health - The FDA's Cult of Tyranny. Other research indicating that increased thyroid activity (hyperthyroidism) contributes to lung cancer pathogenesis was presented, including: The authors also cite animal experimental research which has shown that T4 increases the oxidative stress[6] and spontaneous pulmonary metastases in mice. Reddit and its partners use cookies and similar technologies to provide you with a better experience. I read somewhere about the work done many years ago which was mistakenly read and accepted 28 y/o F Low levels across the board for TSH, T3, and T4, Acid reflux drug linked to more than doubled risk of stomach cancer study, thyroiduk.org - further-reading - thyroid-diagnosis-and-treatment. I wish I could say that my story was atypical. May be of interest: Study: Millions Treated for Hypothyroidism At Risk for, Non-small cell lung cancer - Adenocarcinoma, Non-small cell lung cancer - Squamous cell, Top 5 Questions to Ask Your Lung Cancer Doctor, Patient & Caregiver Network Member Resources, Not A Member Yet? Clin Cancer Res 2011, 30:77. [4] Ratcliffe JG, Stack BH, Burt RW, Radcliffe WA, Spilg WG, Cuthbert J, Kennedy RS: Thyroid function in lung cancer. 2002 Feb ;25(2):106-9. [9] [10] [11] Although we should never forget that LT4 is a life-saving thyroid hormone replacement, and that one should not exclude that the pathological reason that leads to the prescription of LT4 could favor the lung cancer development also. Millions of people who were not only wrongly diagnosed with 'cancers' and subsequently aggressively treated for them with chemotherapy, radiation and surgery, are now being told that they would have been better left undiagnosed and untreated. Also this study finds no link with breast cancer, when others have found a link. Forgot account? One of the main drawbacks of administering T4 in isolation is the possibility that it will not convert adequately to T3, and will therefore 'back up' causing excessive T4 activity, i.e.

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